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ea0022p605 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The regulation of the hypothalamic-pituitary axis is altered in transgenic male mice overexpressing human chorionic gonadotrophin (hCG)

Gonzalez Betina , Di Giorgio Noelia , Ratner Laura , Poutanen Matti , Huhtaniemi Ilpo , Calandra Ricardo , Lux-Lantos Victoria , Rulli Susana

Male transgenic (TG) mice overexpressing both the hCGα- and hCGβ- subunits present elevated levels of circulating hCG, Leydig cell hyperplasia/hypertrophy, elevated androgen levels and infertility (Rulli et al. 2003). In addition, serum FSH is significantly reduced in prepuberal and adult TG males compared with wild-types (WT), and does not change after treatment with the antiandrogen flutamide. The aim of this study was to evaluate the regulation of the hypot...

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Endocrine Abstracts

The regulation of the hypothalamic-pituitary axis is altered in transgenic male mice overexpressing human chorionic gonadotrophin (hCG)

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